- Scharf A, Gührs KH, von Mikecz A. 2015.
Anti-amyloid compounds protect from silica nanoparticle-induced neurotoxicity in the nematode C. elegans.
Nanotoxicology (in press)
- Arnhold F, Gührs KH, von Mikecz A. 2015.
Amyloid domains in the cell nucleus controlled by nucleoskeletal protein lamin B1 reveal a new pathway of mercury neurotoxicity.
PeerJ. Feb 5;3:e754. doi: 10.7717/peerj.754. eCollection 2015.
(PDF)
(PubMed)
- Scharf A, Piechulek A, von Mikecz A. 2013.
Effect of nanoparticles on the biochemical and behavioral aging phenotype of the nematode Caenorhabditis elegans.
ACS Nano. Dec 23;7(12):10695-703. Epub 2013 Nov 23.
(PubMed)
- von Mikecz A, Scharf A. 2013.
Isochronal visualization of transcription and proteasomal proteolysis in cell culture or in the model organism, Caenorhabditis elegans.
Methods Mol Biol. 1042:257-73.
(PubMed)
- Hemmerich PH, von Mikecz AH. 2013.
Defining the subcellular interface of nanoparticles by live-cell imaging.
PLoS One. 8(4):e62018. Epub 2013 Apr 26.
(PDF)
(PubMed)
- Ulbricht T, Alzrigat M, Horch A, Reuter N, von Mikecz A, Steimle V, Schmitt E, Krämer OH, Stamminger T, Hemmerich P. 2012.
PML promotes MHC class II gene expression by stabilizing the class II transactivator.
J Cell Biol. 199(1): 49-63. Epub 2012 Sept 24.
(PDF)
(PubMed)
- Arnhold F, von Mikecz A. 2011.
Quantitative feature extraction reveals the status quo of protein fibrillation in the cell nucleus.
Integr Biol. 3: 761-769. Epub 2011 Jun 20.
(PubMed)
- Andrea Scharf; Petar N. Grozdanov; Roman Veith; Ulrich Kubitscheck; U. Thomas Meier; Anna von Mikecz
2011.
Distant positioning of proteasomal proteolysis relative to actively transcribed genes. Nucleic Acids Research 39: 4612-4627 Epub. 2011 Feb 8.
(PDF)
(PubMed)
- Vordenbäumen S, Braukmann A, Petermann K, Scharf A, Bleck E, von Mikecz A, Jose J, Schneider M. 2011.
Casein {alpha} s1 Is Expressed by Human Monocytes and Upregulates the Production of GM-CSF via p38 MAPK. J Immunol. 186: 592-601. (PubMed)
- Pluskota, A., Horzowski, E., Bossinger, O., and von Mikecz, A. 2009.
In Caenorhabditis elegans Nanoparticle-Bio-Interactions Become Transparent: Silica-Nanoparticles Induce Reproductive Senescence. PLoS One 4:
e6622. (PubMed)
- Chen, M., and A. von Mikecz. 2009.
Nanoparticle-induced cell culture models for neurodegenerative protein aggregation diseases. Inhalation Toxicol. 21(S1): 110-114. (PubMed)
- Chen, M., Singer, L., Scharf, A., and von Mikecz, A. 2008.
Nuclear polyglutamine-containing protein aggregates as active
proteolytic centers. J. Cell Biol. 180: 697-704.
(PubMed)
highlighted in : Nature Chemical Biology 4:231
- Chen, M., Singer, L., Scharf, A., and von Mikecz, A. 2008.
Nuclear polyglutamine-containing protein aggregates as active
proteolytic centers. J. Cell Biol. 180: 697-704.
(PubMed)
- Scharf, A., Rockel, T., and von Mikecz, A. 2007.
Localization of proteasomes and proteasomal proteolysis in the mammalian interphase cell nucleus by systematic application of immunocytochemistry. Histochem. Cell Biol. 127: 591-601.
(PubMed)
- Hippe A, Bylaite M, Chen M, von Mikecz A, Wolf R, Ruzicka T, Walz M.
2006.
Expression and tissue distribution of mouse Hax1. Gene 379: 116-126.
(PubMed)
- Rockel, T., Stuhlmann, D., and von Mikecz, A. 2005.
Proteasomes degrade proteins in distinct subdomains of the human cell nucleus. J. Cell Sci. 118: 5231-5242.
(PubMed)
- Berneburg, M., Gremmel, T., Kürten, V., Schröder, P., Hertel, I., von Mikecz, A., Wild, S., Chen, M., Declercq, L., Matsui, M., Ruzicka, T., and J. Krutmann. 2005.
Creatine supplementation normalises mutagenesis of mitochondrial DNA as well as functional consequences. J. Invest. Dermatol. 125: 213-220.
(PubMed)
- Chen, M. and von Mikecz, A. 2005.
Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles. Exp. Cell Res. 305: 51-62.
(PubMed)
- Chen, M., Tanbajewa, A., Kuhn, A., Ruzicka, T., and von Mikecz, A. 2005.
Recruitment of topoisomerase I (Scl-70) to nucleoplasmic proteasomes in response to xenobiotics suggests a role for altered antigen processing in scleroderma. Arthritis Rheum. 52: 877-884.
(PubMed)
- Welss, T., Sun, J., Irving, J.A., Blum, R., Smith, A. I., Whisstock, J.C., Pike, R.N., von Mikecz, A., Ruzicka, T., Bird, P.I., and H. F. Abts. 2003.
Hurpin is a selective inhibitor of lysosomal cathepsin L and protects keratinocytes from UV-induced apoptosis. Biochemistry 42, 7381-7389.
(PubMed)
- Rockel, T.D., and A. von Mikecz. 2002.
Proteasome-dependent processing of nuclear proteins is correlated with their subnuclear localization. J. Struct. Biol. 140: 189-199.
(PubMed)
- Kießlich, A., von Mikecz, A., and P. Hemmerich. 2002.
Cell cycle-dependent association of PML bodies with sites of active transcription in nuclei of mammalian cells. J. Struct. Biol. 140: 167-179.
(PubMed)
- Chen, M., Hemmerich, P., and A. von Mikecz. 2002.
Platinum-induced autoantibodies target nucleoplasmic antigens related to active transcription. Immunobiol. 206: 474-483.
(PubMed)
- Chen, M., Rockel, T., Steinweger, G., Hemmerich, P., Risch, J., and A. von Mikecz. 2002.
Subcellular recruitment of fibrillarin to nucleoplasmic proteasomes: implications for processing of a nucleolar autoantigen. Mol. Biol. Cell 13: 3576-3587.
(PubMed)
- Chen, M., and A. von Mikecz. 2000.
Specific inhibition of rRNA transcription and dynamic re-location of fibrillarin induced by mercury. Exp. Cell Res. 259: 225-238.
(PubMed)
- von Mikecz, A., Zhang, S., Montminy, M., Tan, E.M., and P. Hemmerich. 2000.
CBP/p300 and RNA-polymerase II colocalize in transcriptionally active domains in the nucleus. J. Cell Biol. 150: 265-274.
(PubMed)
- von Mikecz, A., Neu, E., Krawinkel, U., and P. Hemmerich. 1999.
Human ribosomal protein L7 carries two nucleic acid-binding domains with distinct specificities. Biochem. Biophys. Res. Commun. 258: 530-536.
- Hemmerich, P., Neu, E., Macht, M., Peter, H.-H., Krawinkel, U., and A. von Mikecz. 1998.
Correlation between chlamydial infection and autoimmune response: molecular mimicry between RNA polymerase major subunit from Chlamydia trachomatis and human L7. Eur. J. Immunol. 28: 3857-3866.
- Hemmerich, P., Bosbach, S., von Mikecz, A., and U. Krawinkel. 1997.
Human ribosomal protein L7 binds RNA with an -helical arginine- and lysine-rich domain. Eur. J. Biochem. 254: 549-556.
- Neu, E., Hemmerich, P., Peter, H.H., Krawinkel, U., and A.H. von Mikecz. 1997.
Characteristic epitope recognition of autoantibodies against ribosomal protein L7 in systemic autoimmune diseases. Arthritis Rheum. 40: 661-671.
- von Mikecz, A., Konstantinov, K., Buchwald, D., Gerace, L., and E.M. Tan. 1997.
High frequency of autoantibodies to insoluble cellular antigens in chronic fatigue syndrome. Arthritis Rheum. 40: 295-305.
- Konstantinov, K., von Mikecz, A., Buchwald, D., Jones, J., Gerace, L., and E.M. Tan. 1996.
Autoantibodies to nuclear envelope antigens in chronic fatigue syndrome. J. Clin. Invest. 98: 1888-1896.
- Neumann, F., Hemmerich, P., von Mikecz, A., Peter, H.H., and U. Krawinkel. 1995.
Human ribosomal protein L7 inhibits cell-free translation in reticulocyte lysates and affects the expression of nuclear proteins upon stable transfection into Jurkat T-lymphoma cells. Nucl. Acids Res. 23: 195-202.
- von Mikecz, A.H., Hemmerich, P.H., Peter, H.H., and U. Krawinkel. 1995.
Autoantigenic epitopes on eukaryotic L7. Clin. Exp. Immunol. 100: 205-213.
- Neu, E., von Mikecz, A.H., Hemmerich, P.H., Peter, H.H., Fricke, M., Deicher, H., Genth, E., Krawinkel, U., and Members of the SLE Study Group. 1995.
Autoantibodies against eucaryotic protein L7 in patients suffering from systemic lupus erythematosus and progressive systemic sclerosis : frequency and correlation with clinical, serological and genetic parameters. Clin. Exp. Immunol. 100: 198-204.
- von Mikecz, A., Hemmerich, P., Peter, H.H., and U. Krawinkel. 1994.
Characterization of eucaryotic protein L7 as a novel autoantigen which frequently elicits an immune response in patients suffering from systemic autoimmune diseases. Immunobiol. 192: 137-154.
- von Mikecz, A., Hemmerich, P., Neu, E., Peter, H.H., and U. Krawinkel. 1994.
Das ribosomale Protein L7 als Autoantigen bei Patienten mit systemischem Lupus Erythematodes, Mischkollagenosen und rheumatoider Arthritis. Z. ärtzl. Fortbild. 88: 501-503.
- Hemmerich, P., von Mikecz, A., Neumann, F., Sözeri, O., Wolff-Vorbeck, G., Zoebelein, R., and U. Krawinkel. 1993.
Structural and functional properties of ribosomal protein L7 from humans and rodents. Nucl. Acids Res. 21: 223-231.
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- Arnhold F, Scharf A, von Mikecz A. 2015.
Imaging and quantification of amyloid fibrillation in the cell nucleus.
Methods Mol Biol.;1228:187-202. doi: 10.1007/978-1-4939-1680-1_15.
(PubMed)
- von Mikecz A. 2014.
Pathology and function of nuclear amyloid: Protein homeostasis matters.
Nucleus. 2014 Jul-Aug;5(4):311-7. doi: 10.4161/nucl.29404.
(PDF)
(PubMed)
- von Mikecz, A. 2009.
PolyQ-fibrillation in the cell nucleus: who's bad? Trends Cell Biol. 19: 685-691
(PubMed)
- von Mikecz, A. 2009.
Nuclear protein aggregates: Structure,
function, and topology. Open Biology 2.
(PDF)
- von Mikecz A, Chen M, Rockel T, Scharf A. 2008.
The nuclear ubiquitin-proteasome system: visualization of proteasomes, protein aggregates, and proteolysis in the cell nucleus.
Methods Mol Biol. 463: 191-202.
(PubMed)
- Unfried, K., Albrecht, K., Klotz, L.-O., von Mikecz, A., Grether-Beck, S., and Schins, R.P.F. 2007.
Cellular responses to nanoparticles: target structures and mechanisms. Nanotoxicology 1: 52-71.
- von Mikecz, A. 2006.
The nuclear ubiquitin-proteasome system (nUPS). J. Cell Sci. 2006 119: 1977-1984. (PubMed)
- Chen, M., and A. von Mikecz. 2005.
Xenobiotic-induced recruitment of autoantigens to nuclear proteasomes suggests a role for altered antigen processing in scleroderma. Ann. NY Acad. Sci. 1051: 382-389.
(PubMed)
- von Mikecz, A. 2005.
Meet the nuclear ubiquitin-proteasome system (nUPS). Zellbiologie aktuell 31, 2005/2: 30-33.
- von Mikecz, A. 2005.
Xenobiotic-induced autoimmunity and protein aggregation diseases share a common subnuclear pathology. Autoimmunity Reviews 4: 214-218.
(PubMed)
- Chen, M., and A. von Mikecz. 2005.
Proteasomal processing of nuclear autoantigens in systemic autoimmunity. Autoimmunity Reviews 4: 117-122.
(PubMed)
- Hiepe, F., Riemekasten, G., und A. von Mikecz. 2002.
Anti-Sm-Antikörper - Markerantikörper beim systemischen Lupus erythematodes (SLE). Zeitschr. Rheumatol. 61: 1-2.
(PubMed)
- Chen, M., Dahlmann, B., Hemmerich, P., Rockel, D., and von Mikecz, A. 2000.
Proteasome-dependent processing of nuclear autoantigens. Autoimmunity, Autoantigens Autoantibodies 1: 242-248.
- Kießlich, A., von Mikecz, A., and Hemmerich, P. 2000.
The role of nuclear bodies in transcription. Autoimmunity, Autoantigens, Autoantibodies 1: 110-120.
- Hemmerich, P. and von Mikecz, A. 2000.
Antinuclear antibodies (ANA): fluorescent highlights on structure and function in the nucleus. Int. Arch. Allergy Immunol. 123: 16-27.
(PubMed)
- Peter, H.H., Röther E., Metzger, D., Rump, A., Schlesier, M., von Mikecz, A., Hemmerich, P., Krawinkel, U., Melchers, I. 1994.
Novel autoantibodies in human diseases. VIII European Interferon Workshop, Hannover. J. Interferon Res. 14: 153-155.
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