research

research in cues:

• functional architecture of the cell nucleus
• nuclear ubiquitin-proteasome system (nUPS)
  • localisation of proteasomal proteolysis in the cell nucleus
• cell nucleus and disease
  • cell-based models of
    • systemic autoimmunity
    • protein aggregation diseases
    • cellular senescence
  • anti-nuclear autoantibodies (ANA)
  • autoimmune diseases
  • neurodegenerative diseases
• effects of nanoparticles, heavy metals and other xenobiotics on nuclear structure, function and proteolysis
• environment and quality control in the cell nucleus / subnuclear pathology